I was just wondering if Requiem (or other overhauls like SkyRe) would work with Skywind when it is released. Thanks.
Although, if there is a major
Although, if there is a major character overhaul, it might stop working. And I certainly hope there will be :)
BTW read up on PERMA if you haven't heard of it, being made by the SkyRe maker.

Many mods work for skyrim.
Many mods work for skyrim. Although, since skywind adds new weapons, armor, monsters and maps to the game, you may need compatibility patches to balance the stats of them (no patches for skywind). Other than that you can play with other mods. I currently have 280 mods and I can still visit skywind without ctd'ing