Warning: wall of text
So I was thinking... is there any chance the Thalmor are gonna lose. I mean really? Right now no nation in Tamriel has enough power to stop them, sure they may slow there conquest of Tamriel but I no one can actually invade the dominion and fight them on there home turf.
The thalmor have put to much work in to breaking Skyrim from the empire. Even if ulfric dies would that be enough, I think the thalmor would make sure some one just like him becomes king. Ulfric really isn't as bad or as good as people say he's willing to fight to the last man for his cause but he only seems to care about the nord way of life. Maybe he's what's best for Skyrim but not for Tamriel. The thalmor have even said they want him to win the war.
And if there's a war between the thalmor and the empire there's no way they can win. It's to hard to get troops from Highrock to Cyrodiil (they would have to travel by sea and the thalmor would just blow up all their ships). Not only that, at this point Cyrodiil has to be conquer but the dominion that way the war in Skyrim wouldn't matter in the next game. They could explain it like this: after a nameless assassin killed the emperor, Cyrodiil was without good leadership and with the war weakening them so much when the thalmor attacked the empire couldn't defend themselves.
And i don't think the other nations of tamriel stand a chance either. As long as the thalmor appear as a threat to one nation at a time, the people of tamriel with not be compelled to unify.
Skyrim:
doesn't hate the redguards but would not trust them. especially if they had to allow them access to their province
views the empire as betraying the very person who founded them
especially doesn't trust the brentons(while the nords are off fight on the Cyrodiil border, the brenton would be coming from the reach thus the nords would think "hey how do we know they won't try to conquer the reach again.
Hammerfell:
Views the empire as people who sold them out to the dominion
has been warring with highrock over control of the Illiac bay for 100's of years.
Cyrodiil
views skyrim as fool because they say they fight for talos but all they're doing is destroying the empire he spent his whole life building
Has no hate toward any other nation.
Highrock:
Has been warring with hammerfell for 100's of years
has no hate for anyone else
but to make it all worse all the thalmor have to do is remove the zero stone from the adamantine tower and then they could cause human to disappear for good and undo the mortal creation. (according to Michael Kirkbride and the elder scrolls wiki)
edit: forgot to ask: what do you guy think. does anyone really stand a chance against the thalmor and why.

Nope! they are really hard to
Nope! they are really hard to beat at most times,but an army of them would just be impossible [without cheating].
And with the zero stone they just can`t lose imo.